VDRs are used in many ways, but M&A is the most popular. These procedures require a vast amount of documents to be exchanged and reviewed between the parties involved. The use of a VDR allows the transfer of these documents to be secure as well as reliable and quick.
Members may want to consider conducting an analysis of their VDR to discover patterns that could trigger incidents at sea. This could also allow Members to introduce corrective and preventative actions prior to incidents actually happening.
The vitamin D receptor (VDR) is a transcription factor that regulates the expression/transcription of genes (genomic pathways) and the regulation of enzymes (non-genomic pathways). The VDR is primarily located in the nucleus. It binds ligand, typically 1,25-dihydroxyvitamin D3, to specific DNA sequences in the promoter region of target genes and activates or inhibits transcription.
For transcriptional activation, VDR requires a large multiprotein complex referred to as the mediator complex (DRIP). It includes a range of domains which are linked to the zinc-finger DNA-binding region of the thyroid hormone receptors as well as the 9aaTAD (LXXLL) consensus core sequence, which is found in a large number of transcription factors. The most well-known component of the mediator complex is a protein called Med220, which interacts with VDR/RXR heterodimers ligand-activated by one or more LXXLL motif.
A T > C shift in the FokI Polymorphism of the VDR removes exon 2’s start site for translation and results in a protein that is shorter and has a reduced binding effectiveness to DNA. It also reduces transcriptional activation. This variant has been linked to alterations in calcium absorption and gene expression [54].